The approval of the combined oral contraceptive pill (or “the Pill”) in the 1960s ushered in a sexual revolution as women gained unprecedented control over their reproductive capabilities. But despite much research, the development of a male contraceptive pill has proven more elusive. Researchers at the Dana-Farber Cancer Institute and Baylor College of Medicine have now discovered that a small molecule compound can produce reversible birth control in mice, thereby showing promise as a lead compound for the development of a reversible male contraceptive.