
Manchester scientists have developed a tiny molecular machine that mirrors the function of the ribosome, which builds the proteins in our body’s cells.

Manchester scientists have developed a tiny molecular machine that mirrors the function of the ribosome, which builds the proteins in our body’s cells.

For millennia, humankind has discovered new drugs either through educated guesswork or blind luck. But with the proliferation of advanced computing, a new paradigm has emerged whereby one can find drug targets through simulation and modeling.

Kinesins assume a vital function in our cells: The tiny cargo transporters move important substances along lengthy protein fibers and ensure an effective transportation infrastructure. Biophysicists of the Technische Universitaet Muenchen and the Ludwig Maximillians Universitaet Muenchen have now discovered how some of these transporters can, like cars on a multi-lane motorway, change lanes. The researchers report on this hitherto unknown phenomenon in the current edition of the renowned journal Molecular Cell.

Researchers at the universities of Granada and Barcelona have described for the first time the diffusion of liquid water through nanochannels in molecular terms; nanochannels are extremely tiny channels with a diameter of 1-100 nanometers that scientists use to study the behavior of molecules (nm. a unit of length in the metric system equal to one billionth of a meter that is used in the field of nanotechnology).